Publications

Laszik Z: Pancreatitis and cytomegalovirus infection in a child with Burkitt-type lymphoma. An autopsy study. (In Hungarian with English abstract) Orv Hetilap 1986; 127:277-279.

Laszik Z, Szalay I, Hódi M: Diabetic glomerulosclerosis complicated by glomerulonephritis. (in Hungarian with English abstract) Orv Hetilap 1987; 128:1205-1208.

Laszik Z, Iványi B, Ormos J: Immunofluorescent examination of the kidney post mortem. Histol Histopath 1987; 2:13-18.

Ormos J, Laszik Z: Die endokrine Bauchspeicheldrüse bei chronischer Pankreatitis. (in German with English abstract) Verh Dtsch Ges Path 1987; 71:277-279.

Laszik Z, Pap A, Farkas Gy: A case of primary sclerosing cholangitis mimicking chronic pancreatitis. Int J Pancreatol 1988; 3:503-508.

Laszik Z, Ormos J: The endocrine pancreas in chronic pancreatitis. [The Pancreas in Connection with the Epigastric Unit.] Gustav-Fischer Verlag, Stuttgart-New York 1988; 217-219.

Krenács T, Dobó E, Iványi B, Laszik Z: Preparation of immunogold conjugate and its usefulness in the light and electron microscopic immunohistochemistry. (in Hungarian with English abstract) Morph és Ig Orv Szemle 1988; 28:29-38.

Krenács T, Laszik Z, Dobó E: The light microscopic immunogold silver staining and sensitive immunoperoxidase methods in routine histopathology. (in Hungarian with English abstract) Morph és Ig Orv Szemle 1988; 28:45-52.

Baltás B, Németh J, Pap A, Laszik Z, Karácsonyi S: Zollinger-Ellison syndrome based on our surgically treated cases. (in Hungarian with English abstract) Orv Hetilap 1988; 129:1091-1095.

Laszik Z, Krenács T, Baltás B, Pap A, Karácsonyi S: Studies into gastrinomas and combined carcinomatous carcinoid tumors. Optical light- and electron microscopy and immunohistochemistry. Zentralbl allg Pathol Pathol Anat 1989; 135:657-665. 

Laszik Z, Pap A, Farkas Gy, Ormos J: Endocrine pancreas in chronic pancreatitis. A qualitative and quantitative study. Arch Pathol Lab Med 1989; 113:47-51.

Laszik Z, Krenács T.: S-1OO protein positivity in human pancreases. Acta Morph Hung Acad Sci 1989; 37:117-124.

Laszik Z, Berger Z, Pap A, Tóth G, Varró V: Course and regression of acute interstitial pancreatitis induced in rats by repeated serial subcutaneous cholecystokininoctapeptide injections. Int J Pancreatol 1989; 5:347-358.

Zimmermann T, Laszik Z, Nagy S, Kaszaki J, Joó F: The role of the complement system in the pathogenesis of multiple organ failure in shock. Progress in Clinical and Biological Research. Alan R. Liss. Inc. New York, 1989; 291-297.

Laszik Z, Pap A: The alcoholic pancreatitis. (in Hungarian with English abstract) Orv Hetilap 1989; 130:2527-2531.

Mágori A, Sonkodi S, Laszik Z, Mohácsi G: Glomerulonephritis in diabetic patients. (in Hungarian with English abstract) Morph és Ig Orv Szemle 1989; 29:269-274.

Laszik ZG, Kallajoki M, Hyppia T, Rima B, Aho HJ, Nevalainen TJ: Mumps, enteroviruses and human acute pancreatitis. In situ hybridization studies. Scand J Gastroenterol 1990; 25:906-910.

Krenács T, Dobó E, Laszik Z: Characteristics of endocrine pancreas in chronic pancreatitis as revealed by simultaneous immunocytochemical demonstration of hormone production. The J Histotechnol 1990; 13:213-218.

László A, Laszik Z, Klujber L, Havass Z: Biochemical and ultrastructural diagnostic problems in mucolipidoses. Acta Pediatrica Hungarica 1991; 31:423-432.

Márton J, Farkas Gy, Lonovics J, Laszik Z: A case of inflammatory fibroid polyp of unusual localization. (in Hungarian with English abstract) Orv Hetilap 1991; 132:1823-1825.

Hietaranta AJ, Laszik ZG, Aho HJ, Kortesuo PT, Nevalainen TJ: The role of phospholipase A2 in pancreatic acinar cell injury. Int J Pancreatol 1991; 8:187-201.

Krenács T, Iványi B, Bozóky B, Laszik Z, Krenács L, Rázga Zs, Ormos J: Postembedding immuno-electron microscopy using immunogold-silver staining (IGSS) in Epon 812, Durcupan ACM and LR-White resin embedded tissues. The J Histotechnol 1991; 14:75-80.

Endreffy E, Túri S, Laszik Z, Bereczki C, Kása K: The effects of vitamin E on tissue oxidation in nephrotoxic (anti-glomerular basement membrane) nephritis. Pediatric Nephrology 1991; 5(3):312-317.

Iványi B and Laszik Z: Postmortem immunofluorescence and electron microscopy for diagnosing immune complex disease. The J Histotechnol 1992; 15:23-26.

Nagy I, Hajnal F, Mohácsi G, Németh J, Laszik Z, Pap A: Pancreatic trophism in experimental liver cirrhosis. Int J Pancreatol 1993; 14:157-166.

Gocze PM, Laszik Z: Smoking cessation and risk of stroke in women (letter; comment). JAMA 1993; 269:2213-2214.

Silva FG, Nadasdy T, Laszik Z: Immunohistochemical and lectin dissection of the human nephron in health and disease. Arch Pathol Lab Med 1993; 117:1233-1239.

Nadasdy T, Laszik Z, Blick KE, Johnson DL, Silva GF: Tubular atrophy in the end-stage kidney: a lectin and immunohistochemical study. Human Pathol 1994; 25:22-28.

Laszik Z, Carson CW, Nadasdy T, Johnson DL, Lerner MR, Brackett DJ, Esmon CT, Silva FG: Lack of suppressed renal thrombomodulin expression in a septic rat model with glomerular thrombotic microangiopathy. Lab Invest 1994; 70:862-867.

Nadasdy T, Smith J, Laszik Z, Johnson D, Silva FG: Absence of association between cytomegalovirus (CMV) infection and obliterative transplant arteriopathy in renal allograft rejection. Modern Pathol 1994; 7:289-294.

Nadasdy T, Laszik Z, Blick KE, Johnson D, Silva FG: Proliferative activity of intrinsic cell populations in the normal human kidney. J Am Soc Nephrol 1994; 4:2032-2039.

Laszik Z, Nadasdy T, Johnson D, Lerner MR, Brackett DJ, Silva FG: Glomerular endothelial IL-1 expression in septic rats. Circulatory Shock 1994; 43:115-121.

Nadasdy T, Laszik Z, Blick KE, Johnson DL, Cohen AH, Nast C, Ormos J, Silva FG: Human acute tubular necrosis. A lectin and immunohistochemical study. Human Pathol 1995; 26:230-239.

Nadasdy T, Laszik Z, Lajoie G, Blick KE, Wheeler DE, Silva FG: Proliferative activity of cyst epithelia in various forms of polycystic renal disease. J Am Soc Nephrol 1995; 5:1462- 1468.

Laszik Z, Jansen PJ, Cummings RD, TF Tedder, McEver RP, Moore KL: P-selectin glycoprotein ligand-1 is broadly expressed in cells of myeloid, lymphoid, and dendritic lineage and in some non-hematopoietic cells. Blood 1996; 88:3010-3021.

Lajoie G, Nadasdy T, Laszik Z, Blick KE, Silva FG: Mast cells in acute cellular rejection of human renal allografts. Modern Pathol 1996; 9:1118-1125.

Laszik Z, Mitro A, Taylor FB, Jr., Esmon CT: The newly identified protein C receptor is present primarily on vascular endothelium of large arteries and veins: implications for the CURRICULUM VITAE ZOLTAN G. LASZIK, M.D., PH.D. REVISED JUNE 2009 12 control of protein C pathway. Circulation 1997; 96:3633-3640.

Esmon CT, Ding W, Yasuhiro K, Gu J-M, Ferrel G, Regan LM, Stearns-Kurosawa DJ, Kurosawa S, Mather T, Laszik Z, Esmon NL: The protein C pathway: new insights. Thrombosis and Haemostasis 1997; 78(1):70-74.

Bottles KD, Laszik Z, Morrissey JH, Kinasewitz GT: Tissue factor expression is inducible in mesothelial cells both in vivo and in vitro. American Journal of Respiratory Cell and Molecular Biology 1997; 17:164-172.

Nadasdy, T, Lajoie, G, Laszik, Z, Blick, KE, Molnar-Nadasdy, G, Silva, FG: Cell proliferation in the developing human kidney. Pediatric and Developmental Pathology 1998; 1:49-55.

Nagy I, Laszik Z, Mohacsi G: Dose-dependent pancreatotrophic effect of cholecystokininoctapeptide in the rat: the influence of starvation. Pharmacol Res 1998; 37(4):309-319.

Esmon CT, Xu J, Gu J, Qu D, Laszik Z, Ferrel G, Stearns-Kurosawa J, Kurosawa S, Taylor FB, Jr., Esmon NL: Endothelial protein C receptor. Thrombosis Research 1999; 82:251-258.

Yao L, Setiadi H, Xia L, Laszik Z, Taylor FB Jr, McEver RP: Divergent inducible expression of P-selectin and E-selectin in mice and primates. Blood 1999; 94:3820-3828.

Roberts CM, Tani PH, Bridges LC, Laszik Z, Bowditch RD: MDC-L, a novel metalloproteinase disintegrin cysteine-rich protein family member expressed by human lymphocytes. J Biol Chem 1999; 274(41):29251-29259.

Nagy I, Nemeth J, Laszik Z: Effect of L-aminocarnitine, an inhibitor of mitochondrial fatty acid oxidation on the exocrine pancreas and liver in fasted rats. Pharmacol Res 2000; 41:9- 17.

Zhou XJ, Laszik Z, Ni Z, Brackett DJ, Lerner MR, Silva FG, Vaziri ND: Down regula- tion of renal endothelial nitric oxide synthase expression in experimental glomerular thrombotic microangiopathy. Lab Invest 2000; 80:1079-1087.

Taylor FB Jr, Stearns-Kurosawa DK, Kurosawa S, Ferrel G, Chang A, Laszik Z, Kosanke S, Peer G, Esmon CT: The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis. Blood 2000; 95:1680-1686.

Zhou XJ, Laszik Z, Wang XQ, Silva FG, Vaziri ND: Association of renal injury with increased oxygen free radical activity and altered nitric oxide metabolism in chronic experimental hemosiderosis. Lab Invest 2000 Dec; 80(12):1905-14.

Milagros S, Nadasdy MGy, Laszik Z, Nadasdy T: Outcome of renal transplantation in fibrillary glomerulonephritis. Clin Nephrol 2001; 55:159-66. CURRICULUM VITAE ZOLTAN G. LASZIK, M.D., PH.D. REVISED JUNE 2009 13

Faust SN, Levin M, Harrison O, Goldin RD, Lockhart M, Kondaveeti S, Laszik Z, Esmon CT, Heyderman RS: Dysfunction of the endothelial protein C pathway in the coagulopathy of meningococcal sepsis. NEJM 2001; 345:408-416.

Laszik ZG, Zhou XJ, Ferrel GL, Silva FG, Esmon CT: Downregulation of endothelial cell protein C receptor and thrombomodulin in coronary atherosclerosis. Am J Pathol 2001; 159:797-802.

Zhou XJ, Wang XQ, Silva FG, Vaziri ND, Laszik Z: Nitric oxide synthase expression in oxidative stress-induced hypertension in normal rats. J Pharmacol Exp Ther 2002; 300(3):762-767.

Laszik ZG, Blakey GL: Searching for a valid animal model of hemolytic uremic syndrome. Am J Clin Pathol 2002; 118:323-325. Editorial.

Svensson AM, Waters BL, Laszik ZG, Simmons-Arnold L, Goodwin A, Beatty BG and Bovill EG: The Protein C system in placental massive perivillous fibrin deposition. Blood Coagulation & Fibrinolysis 2004; 15 (6): 491-495.

Blakey BL, Laszik ZG: Laser-assisted Microdissection of the Kidney: Fundamentals and Applications. Journal of Molecular Histology, 2004; 35 (6): 581-587.

Li Y, Gusev Y, Laszik Z, Do S, Brackett D, Ni Y, Cheung JY: Assessment of Compression Effects on Digital Microscopic Images of Tumor Samples. Computers and Their Applications 2004: 378-381

Davis WG and Laszik ZG: Prevalence of pancreatic intraepithelial neoplasia in association with adenocarcinoma of the head of the pancreas, distal common bile duct, and ampulla of Vater, as well as chronic pancreatitis in Whipple resection specimens. Manuscript in Preparation.

Laszik ZG, Zhou XJ, Silva FG, Esmon CT, Vaziri ND: Thrombomodulin (TM) but not endothelial cell protein C receptor (EPCR) mRNA is downregulated in streptozotocininduced diabetic rat kidneys. Manuscript in Preparation.

Laszik ZG, Esmon CT: Thrombomodulin (TM) and endothelial protein C receptor (EPCR) are upregulated in ischemia/reperfusion (I/R)-induced acute renal failure in rat kidneys. Manuscript in Preparation.

Hassan R, Laszik ZG,Lerner M, Postier M, Pastan I, Brackett D: Mesothelin, a cell surface glycoprotein is highly expressed in pancreaticobiliary adenocarcinomas but not in normal pancreas or chronic pancreatitis. Am J Clin Pathol 2005; 124:838-845

Bates JM Jr., Raffi HM, Prasadan K, Mascarenhas R, Laszik Z, Maeda N, Hultgren S, Kumar S: Tamm-Horsfall Protein Knockout Mice are More Prone to Urinary Tract Infection. Kidney International 2004; 65(3): 791-797. CURRICULUM VITAE ZOLTAN G. LASZIK, M.D., PH.D. REVISED JUNE 2009 14

Raffi HS, Bates JM, Jr., Laszik ZG, Kumar S: Tamm-Horsfall Protein acts as a general host defense factor against bacterial cystitis. Am J Nephrol. 2005; 17;25(6): 570-578.

Baluja P, Haragsim L, Laszik ZG: Chronic Allograft Nephropathy. Invited Review. Advances in Chronic Renal Disease 2006; 13:56-61. (with cover photograph)

Khan S, Haragsim L, Laszik ZG: HIV-associated nephropathy. Advances in Chronic Renal Disease, 2006; 13(3):307-13.

Osunkoya AO, Agte SD, Laszik ZG. A 67-year-old woman with chronic proteinuria. Focal segmental and global glomerulosclerosis with light microscopic and ultrastructural features consistent with Fabry disease. Arch Pathol Lab Med. 2006; 130(6):e93-5.

Raffi HS, Bates JM, Jr., Laszik ZG, Kumar S: Tamm-Horsfall protein knockout mice do not develop medullary cystic kidney disease. Kidney Int. 2006; 69(10):1914-5.

Maier S, Gross J, Hamlin K, Maier J, Workman J, Kim-Howard X, Schoeb T, Laszik Z, Farris D: Proteinuria of Non-autoimmune Origin in Wild-type FVB/NJ mice. Comparative Medicine, 57(3), 2007.

Siami K, Kojouri K, Swisher KK, Selby GB, George JN, and Laszik ZG: Thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation. An autopsy study. Transplantation. 2008; 85(1):22-28.

Latif F, Peyton M, Laszik ZG, Solomon E, Sivaram, C: Infective endocarditis of a papillary fibroelastoma on the Chiari network of right atrium. J Am Soc Echocardiogr. 2008 21(2):188.e3-4.

Ju T, Lanneau GS, Gautam T, Wang Y, Xia B, Stowell SR, Willard MT, Wang W, Xia Y, Zuna RE, Laszik ZG, Benbrook DM, Hanigan MH, and Cummings RD: Human Tumor Antigens Tn and Sialyl Tn Arise from Mutations in Cosmc. Cancer Res. 2008; 68(6):1636- 46.

Bluestone JA, Liu W, Yabu YM, Laszik ZG, Putnam A, Belingheri M, Gross DM, Townsend RM, Vincenti F: The effects of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation. American Journal of Transplantation. 2008; 8:1-11.

Raffi HS, Bates JM, Laszik ZG, Buffington T, Kumar S: Tamm-Horsfall Protein knockout mice have increased stress induced micturition. Neurourology and Urodynamics. 2009; 26:1.

Raffi HS, Bates JM, Laszik ZG, Kumar S: Tamm-Horsfall Protein Protects Against Urinary Tract Infection by Proteus mirabilis. The Journal of Urology. 2009;181(5):2332-8.

Jen KY, Haragsim L, Laszik ZG. Kidney microvasculature in health and disease. Contrib Nephrol. 2011;169:51-72. doi: 10.1159/000313945. Epub 2011 Jan 20.

Anand S, Yabu JM, Melcher ML, Kambham N, Laszik Z, Tan JC.Cytomegalovirus in the transplanted kidney: a report of two cases and review of prophylaxis. NDT Plus. 2011 Oct;4(5):342-5. doi: 10.1093/ndtplus/sfr074. Epub 2011 Jul 18.

Jen KY, Nguyen TB, Vincenti FG, Laszik ZG. C4d/CD34 double-immunofluorescence staining of renal allograft biopsies for assessing peritubular capillary C4d positivity.Mod Pathol. 2012 Mar;25(3):434-8. doi: 10.1038/modpathol.2011.168. Epub 2011 Oct 28.

Jen KY, Olson JL, Brodsky S, Zhou XJ, Nadasdy T, Laszik ZG. Reliability of whole slide images as a diagnostic modality for renal allograft biopsies. Hum Pathol. 2013 May;44(5):888-94. doi: 10.1016/j.humpath.2012.08.015. Epub 2012 Nov 28.

Meehan SM, Chang A, Gibson IW, Kim L, Kambham N, Laszik Z. A study of interobserver reproducibility of morphologic lesions of focal segmental glomerulosclerosis. Virchows Arch. 2013 Feb;462(2):229-37. doi: 10.1007/s00428-012-1355-3. Epub 2012 Dec 21.

Jen KY, Fix OK, Foster EN, Laszik ZG, Ferrell LD. Monoclonal light chain deposits within the stomach manifesting as immunotactoid gastropathy. Ultrastruct Pathol. 2015 Feb;39(1):62-8. doi: 10.3109/01913123.2014.939796. Epub 2014 Sep 5.

Winger BA, Foy E, Sud SR, MacKenzie JD, Pua HH, Lau AH, Heyman MB, Laszik Z, Tureen J. Mycobacterium bovis Enterocolitis in an Immunocompromised Host. J Pediatr Gastroenterol Nutr. 2016 Jul;63(1):e17-9. doi: 10.1097/MPG.0000000000000528.

Dobi D, Bodó Z, Kemény É, Boda K, Szenohradszky P, Szederkényi E, Laszik ZG, Iványi B. Morphologic Features and Clinical Impact of Arteritis Concurrent with Transplant Glomerulopathy. Pathol Oncol Res. 2016 Jan;22(1):15-25. doi: 10.1007/s12253-015-9962-3. Epub 2015 Jul 23.

Scharschmidt TC, Vasquez KS, Pauli ML, Leitner EG, Chu K, Truong HA, Lowe MM, Sanchez Rodriguez R, Ali N, Laszik ZG, Sonnenburg JL, Millar SE, Rosenblum MD. Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin. Cell Host Microbe. 2017 Apr 12;21(4):467-477.e5. doi: 10.1016/j.chom.2017.03.001. Epub 2017 Mar 23.

Li Y, Lee MM, Worters PW, MacKenzie JD, Laszik Z, Courtier JL. Pilot Study of Renal Diffusion Tensor Imaging as a Correlate to Histopathology in Pediatric Renal Allografts. AJR Am J Roentgenol. 2017 Jun;208(6):1358-1364. doi: 10.2214/AJR.16.17418. Epub 2017 Apr 5.

Poynton CB, Lee MM, Li Y, Laszik Z, Worters PW, Mackenzie JD, Courtier J. Intravoxel incoherent motion analysis of renal allograft diffusion with clinical and histopathological correlation in pediatric kidney transplant patients: A preliminary cross-sectional observational study. Pediatr Transplant. 2017 Sep;21(6). doi: 10.1111/petr.12996. Epub 2017 Jun 27.

Chandran S, Tang Q, Sarwal M, Laszik ZG, Putnam AL, Lee K, Leung J, Nguyen V, Sigdel T, Tavares EC, Yang JYC, Hellerstein M, Fitch M, Bluestone JA, Vincenti F. Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants. Am J Transplant. 2017 Nov;17(11):2945-2954. doi: 10.1111/ajt.14415. Epub 2017 Aug 14.

Dobi D, Laszik ZG. In Situ Hybridization and Double Immunohistochemistry for the Detection of VEGF-A mRNA and CD34/Collagen IV Proteins in Renal Transplant Biopsies. Methods Mol Biol. 2018;1788:131-143. doi: 10.1007/7651_2017_86.

Vasquez JJ, Hussien R, Aguilar-Rodriguez B, Junger H, Dobi D, Henrich TJ, Thanh C, Gibson E, Hogan LE, McCune J, Hunt PW, Stoddart CA, Laszik ZG. Elucidating the Burden of HIV in Tissues Using Multiplexed Immunofluorescence and In Situ Hybridization: Methods for the Single-Cell Phenotypic Characterization of Cells Harboring HIV In Situ. J Histochem Cytochem. 2018 Jun;66(6):427-446. doi: 10.1369/0022155418756848. Epub 2018 Feb 20.

Walavalkar V, Adey DB, Laszik ZG, Jen KY. Severe Renal Allograft Rejection Resulting from Lenalidomide Therapy for Multiple Myeloma: Case Report. Transplant Proc. 2018 Apr;50(3):873-876. doi: 10.1016/j.transproceed.2018.01.014.

Sigdel TK, Nguyen M, Dobi D, Hsieh SC, Liberto JM, Vincenti F, Sarwal MM, Laszik Z. Targeted Transcriptional Profiling of Kidney Transplant Biopsies. Kidney Int Rep. 2018 Feb 3;3(3):722-731. doi: 10.1016/j.ekir.2018.01.014. eCollection 2018 May.